Tracking and elucidating alphavirus host protein interactions


03-Oct-2019 17:42

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This restriction is overcome when cells are co-infected with vaccinia virus (VACV), a vertebrate DNA virus.

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This protein increases the stability of the proteins in the RNA virus, most likely by stopping the moth from breaking them down. suggest that it might be possible to use a combination of RNA viruses and the A51R protein to keep the number of gypsy moths in check.The gypsy moth (Lymantria dispar) has been one of the most prolific North American hardwood forest pests since its accidental release in the late 1800’s (Sparks et al., 2013). dispar and other Lepidopterans to virus infection is of particular importance in designing new and effective virus-based biocontrol strategies to minimize the devastating economic impact these species continue to have on the forest industry (Sparks et al., 2013). dispar-derived cell lines are susceptible to a wide variety of invertebrate DNA viruses, and as such, they are often used in virus-host studies (Sparks and Gundersen-Rindal, 2011). dispar-derived LD652 cells can also support a limited infection by vaccinia virus (VACV), a vertebrate poxvirus encoding a large ds DNA genome (Li et al., 1998).During infection of LD652 cells, VACV undergoes early gene expression, DNA replication and late gene expression, but the infection is abortive due to a defect in one or more steps of virion morphogenesis (Li et al., 1998).These viruses only infect invertebrate hosts and several cannot productively replicate in cultured cells (Short and Dorrington, 2012).

Furthermore, to our knowledge, (−)-sense ss RNA viruses have not been previously reported to productively infect Lepidopteran hosts.Viruses represent a constantly evolving challenge to the fitness and survival of their cellular hosts.