Pharmacology of non sedating antihistamines
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These sprays should be considered first-line treatment in moderate to severe allergic rhinitis.Combination treatments containing both corticosteroids and antihistamines are also available.However, for promethazine there is a risk of severe tissue injury, including gangrene, with both intramuscular and intravenous administration.
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Drugs can help and oral antihistamines are one of the mainstays of treatment.
Antihistamines have no role in the acute management of anaphylaxis.
Antihistamines are used in the management of allergic conditions.
Sedating antihistamines can also have anticholinergic effects that can be particularly problematic in older patients who are more susceptible to adverse effects such as dry mouth, urinary retention and delirium.
Sedating antihistamines are still favoured by some, as parenteral formulations are available.Allergic rhinitis may be seasonal (usually due to grass, tree or weed pollens) or perennial (due to triggers such as pet hair, house dust mite or mould).
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