They were due to face Petra Mandula and Patricia Wartusch in the final, but they withdrew and Hantuchová and Habšudová won in a walkover. Her final tournament of the year was the Advanta Championships of Philadelphia.
In the first round, she beat Alexandra Stevenson, who retired injured after the end of the first set. Hantuchová began 2001 at the Adidas International in Sydney, where she lost in the first qualifying round.
She lost the quarterfinal to Rita Kuti-Kis, 4–6, 4–6.
She did not enter the qualifiers for that year's French Open.
She was part of the Slovak team that won the 2002 Fed Cup and the 2005 Hopman Cup.
Hantuchová reached her second quarterfinal of the year at the BGL Luxembourg Open when she beat Virginie Razzano in the first round and Nathalie Tauziat in the second round.