Aymptomatic hsv 2 dating
Failure to detect HSV by culture or PCR, especially in the absence of active lesions, does not indicate an absence of HSV infection because viral shedding is intermittent.
Cytologic detection of cellular changes associated with HSV infection is an insensitive and nonspecific method of diagnosing genital lesions (i.e., Tzanck preparation) and therefore should not be relied on.
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The clinical diagnosis of genital herpes can be difficult, because the painful multiple vesicular or ulcerative lesions typically associated with HSV are absent in many infected persons.
Recurrences and subclinical shedding are much more frequent for genital HSV-2 infection than for genital HSV-1 infection .
Providers should only request type-specific glycoprotein G (g G)-based serologic assays when serology is performed for their patients .
Both laboratory-based assays and point-of-care tests that provide results for HSV-2 antibodies from capillary blood or serum during a clinic visit are available.
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Although a direct immunofluorescence (IF) assay using fluorescein-labeled monoclonal antibodies is also available to detect HSV antigen from genital specimens, this assay lacks sensitivity Both type-specific and type-common antibodies to HSV develop during the first several weeks after infection and persist indefinitely.